Lupus Nephritis diagnosed by stand-alone renal histopathological findings in a middle-aged male.
Lupus Nephritis diagnosed by stand-alone renal histopathological findings in a middle-aged male
Keywords:
Full house immunofluorescence, Sub-epithelial, subendothelial, Tubulo-reticular inclusions
Abstract
Systemic lupus erythematosus (SLE) is a systemic autoimmune condition, characterized by the production of autoantibodies, predominantly against nuclear antigens. It primarily affects women of childbearing age. Men account for 4-22% of all cases in various series (1,2). Lupus nephritis can be diagnosed with high sensitivity and specificity based on histopathological criteria alone (3). We report lupus nephritis in a 50-year-old male diagnosed solely on renal histopathological findings.
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References
1. Lu L-J, Wallace D, Ishimori M, et al. Male systemic lupus erythematosus:a review of sexdisparities in this disease.Lupus. 2010; 19:119–29.
2. Cervera R, Khamashta MA, Hughes GRV. The Euro-lupusproject: epidemiology of systemic lupus erythematosus inEurope. Lupus. 2009; 18:869–74.
3. Kudose S, Santoriello D, Bomback AS, Stokes MB, D'Agati VD, Markowitz GS. Sensitivity and specificity of pathological findings to diagnose lupus nephritis. Clin J Am Soc Nephrol.2019; 14(11): 1605-15.
4. Resende AL, Titan SM, Barros RT, Woronik V. Worse renal outcome of lupus nephritis in male patients: a case-control study. Lupus. 2011; 20:561-67.
5. Bernatsky S, Boivin JF, Joseph L, Manzi S, Ginzler E, Gladman DD, et al. Mortalityin systemic lupus erythematosus. Arthritis Rheum 2006; 54:2550-57.
6. RabbaniMA, Habib HB, IslamM, Ahmad B, Majid S, Saeed W, et al. Survival analysisand prognostic indicators of systemic lupus erythematosus in Pakistani patients.Lupus 2009; 18:848-55.
7. Flower C, Hennis AJ, Hambleton IR, Nicholson GD, Liang MH. Systemic lupuserythematosus in an Afro-Caribbean population: incidence, clinical manifestations, and survival in the Barbados National Lupus Registry. Arthritis Care Res 2012; 64:1151-58.
8. Boddaert J, Huong DL, Amoura Z, Wechsler B, Godeau P, Piette JC. Late-onset
systemic lupus erythematosus: a personal series of 47 patients and pooled analysis
of 714 cases in the literature. Med (Baltimore) 2004; 83:348-59.
9. Urrestarazú A, Otatti G, Silvariño R, Garau M, Coitiño R, Alvarez A, Gonzalez E, Gadola L, Praga M, Noboa O. Lupus Nephritis in Males: Clinical Features, Course, and Prognostic Factors for End-Stage Renal Disease. Kidney Int Rep. 2017 Jun 16;2(5):905-12.
10. Tan TC, Fang H, Magder LS, et al. Differences between male and female systemic lupus erythematosus in a multiethnic population. J Rheumatol. 2012; 39:759–69.
11. Ding Y, He J, Go JP, et al. Gender differences are associated with the clinical features of systemic lupus erythematosus. Chin Med J (Engl). 2012; 125:2477–81.
2. Cervera R, Khamashta MA, Hughes GRV. The Euro-lupusproject: epidemiology of systemic lupus erythematosus inEurope. Lupus. 2009; 18:869–74.
3. Kudose S, Santoriello D, Bomback AS, Stokes MB, D'Agati VD, Markowitz GS. Sensitivity and specificity of pathological findings to diagnose lupus nephritis. Clin J Am Soc Nephrol.2019; 14(11): 1605-15.
4. Resende AL, Titan SM, Barros RT, Woronik V. Worse renal outcome of lupus nephritis in male patients: a case-control study. Lupus. 2011; 20:561-67.
5. Bernatsky S, Boivin JF, Joseph L, Manzi S, Ginzler E, Gladman DD, et al. Mortalityin systemic lupus erythematosus. Arthritis Rheum 2006; 54:2550-57.
6. RabbaniMA, Habib HB, IslamM, Ahmad B, Majid S, Saeed W, et al. Survival analysisand prognostic indicators of systemic lupus erythematosus in Pakistani patients.Lupus 2009; 18:848-55.
7. Flower C, Hennis AJ, Hambleton IR, Nicholson GD, Liang MH. Systemic lupuserythematosus in an Afro-Caribbean population: incidence, clinical manifestations, and survival in the Barbados National Lupus Registry. Arthritis Care Res 2012; 64:1151-58.
8. Boddaert J, Huong DL, Amoura Z, Wechsler B, Godeau P, Piette JC. Late-onset
systemic lupus erythematosus: a personal series of 47 patients and pooled analysis
of 714 cases in the literature. Med (Baltimore) 2004; 83:348-59.
9. Urrestarazú A, Otatti G, Silvariño R, Garau M, Coitiño R, Alvarez A, Gonzalez E, Gadola L, Praga M, Noboa O. Lupus Nephritis in Males: Clinical Features, Course, and Prognostic Factors for End-Stage Renal Disease. Kidney Int Rep. 2017 Jun 16;2(5):905-12.
10. Tan TC, Fang H, Magder LS, et al. Differences between male and female systemic lupus erythematosus in a multiethnic population. J Rheumatol. 2012; 39:759–69.
11. Ding Y, He J, Go JP, et al. Gender differences are associated with the clinical features of systemic lupus erythematosus. Chin Med J (Engl). 2012; 125:2477–81.
Published
2020-03-13
How to Cite
1.
Sheikh RY, Bhat NA, Mangal R, Sharma A. Lupus Nephritis diagnosed by stand-alone renal histopathological findings in a middle-aged male. jms [Internet]. 2020Mar.13 [cited 2026Aug.11];23(1):41-4. Available from: http://www.jmsskims.org/index.php/jms/article/view/506
Section
Case Reports
